Effects of gadolinium ions upon rat prostatic cancer cell lines of markedly different metastatic potential
作者： Jason Verrall , Scott P Fraser , Mustafa B.A Djamgoz
DOI: 10.1016/S0304-3835(99)00234-7
关键词:
摘要: The effects of gadolinium chloride, a non-specific blocker mechanosensitive ion channels (MSICs), upon the motility and proliferation two Dunning rat prostatic tumour cell lines markedly different metastatic potential were investigated. Gadolinium (2-10 microM) caused dose-dependent increase in distance moved 'wound' assays over 48-h testing period. highly MAT-LyLu line was significantly more sensitive to Gd3+, weakly AT-2 cells responding only at highest concentration (10 used. There no effect on cells' proliferative rates. These data suggest that could play role metastasis by modulating migration.
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