Functional Genomics of Pathogenesis

摘要: Abstract Functional genomics is a global, systematic, and comprehensive approach to elucidating the processes pathways involved in various physiological states. An array of functional platforms such as transcriptomics, proteomics, metabolomics, ionomics, fluxomics, secretomics, etc., facilitates elucidation pathogenesis mechanisms, especially host–pathogen interactions. A handful complete genome sequences pathogens well hosts serve employ high-throughput approaches. Transcriptome analysis promising tool analyze global gene expression patterns. Simultaneous transcriptome host pathogen provides more insights into signaling regulatory networks during pathogenesis. Proteome illustrating bacterial In addition “omics” approaches, transposon mutagenesis-based approaches provide new clues interactions information on genes essential for infection.