Role of prostaglandins in regulation of pancreatic enzyme secretion by various diets.

摘要: We have demonstrated by the use of isolated rat pancreatic acini that exogenous prostaglandins E type inhibit secretagogue-stimulated amylase secretion. here studied whether pancreas is a source prostaglandin synthesis and mediate regulation enzyme secretion various diets. Prostaglandin E2 was measured immunoassay in from either normal animals or after 10 days feeding with different Acini were prepared collagenase digestion. Amylase stimulation cholecystokinin presence absence indomethacin, an inhibitor synthesis. concentration comparable to other organs such as kidney liver. Feeding diet enriched proteins caused increase cholecystokinin-stimulated maximal decrease concentration. Incubation indomethacin stimulated conclude diets may be mediated prostaglandins.