Positive Mediators of Cell Proliferation in Neoplastic Transformation

摘要: Cancer is not a single disease, but collection of diseases all which are related by common root cause: the loss controlled cell growth. begins as clonal that is, it stems from genetic corruption cell. This conversion normal into neoplastic state multi-step phenomenon called transformation and requires accumulation several mutations. Some these mutations enhance activity growth-promoting cellular processes, whereas other undermine regulatory mechanisms designed to keep replication in check. Transformed cells differ with respect many observable characteristics, including alterations growth parameters behavior. Damage growth-regulation DNA repair permit acquired somatic remain uncorrected accumulate. As tumor population grows, specific vary one next, causing progression entity genetically phenotypically heterogeneous cells.