The use of psycho-acoustical transitional sessions in patients suffering of moderate and severe Alzheimer's disease

摘要: The Psycho-Acoustical Transitional (PAT) session is a completely defined setting from mathematical-physical point of view that promotes large-scale functional connectivity between neural populations. Phenomenologically this phenomenon can be described as modulation the state consciousness, inducing unfolding clinical ecstatic in normal subjects, improving for at least 48 hours psycho-physical performances and enhancing “flow” state. A multi-gradient micro-synchronized fractal sound stimulus (Pink Noise) used, reproduced following procedures foreseen AVS Virtual Audio Standard ®’ s audio reproducing system during 20 minutes listening session. study was organized to evaluate if PAT sessions could induce (positive) change Alzheimer’s affected recovered nurse (Fondazione Giroldi-Forcella-Ugoni) their total inability conduce an autonomous life. Six subjects were selected, three testable non seriously compromised mental abilities. Mini Mental State Evaluation (MMSE), Token Corsi test have been evaluated before, after exposition 13 Sessions, once week, 4 months. didn’t show significant improvement abilities remained end evaluation period. showed score’s increase (+ 50–150%) 50–110%), less evident MMSE test. It seems topologic memory, may “restoring” primary space representation (Finsterle 2007) opening some new paths subcortical cortical areas. These data sustain idea sessions’ effects are related brain’s “flexibility” computation abilities, widening research field concerning methodologies able top-down/bottom-up communication possible applications.