Development of virus-specific CD4+ T cells during primary cytomegalovirus infection

作者: Rob J. Rentenaar , Laila E. Gamadia , Nicolette van derHoek , Frank N.J. van Diepen , René Boom

DOI: 10.1172/JCI8229

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摘要: Although virus-specific CD4(+) T cells have been characterized extensively in latently infected individuals, it is unclear how these protective T-cell responses develop during primary virus infection humans. Here, we analyzed the kinetics and characteristics of cytomegalovirus-specific (CMV-specific) course CMV kidney transplant recipients. Our data reveal that, as first sign specific immunity, circulating CMV-specific become detectable with a median 7 days after appearance CMV-DNA peripheral blood. These produce helper 1 type (Th1) cytokines IFNgamma TNFalpha, but not 2 (Th2) cytokine IL4. In infection, vast majority features recently activated naive that they coexpress CD45RA CD45R0 appear to be cell cycle. contrast, people who recovered from earlier life, do cycle express surface markers characteristic memory cells. After initial rise, decline rapidly. During this phase, strong rise IgM IgG anti-CMV antibody titers occurs, concomitant reduction circulation.

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