Controlling Protein Association and Subcellular Localization With a Synthetic Ligand That Induces Heterodimerization of Proteins

摘要: Extracellular growth and differentiation factors induce changes in gene expression the nucleus by initiating a series of protein associations that alter subcellular localization intracellular signaling proteins. Initial events involve receptor homo- or heterodimerization subsequent recruitment cytosolic proteins to inner leaflet plasma membrane. Intermediate translocation into nucleus. Late transcriptional activators vicinity specific genes nucleus, resulting increased transcription. The ability signals at each these three phases pathways is illustrated use heterodimeric chemical inducer dimerization causes proximal relationship between two different target