Methods and compounds useful in treating pruritus, and methods for identifying such compounds

作者: David M. Mills , Andew J. Grottick , Zheng Wei , Brian M. Smith

DOI:

关键词:

摘要: The present invention relates to methods of using histamine 3 receptor (H3R) antagonists treat pruritus or itch in an individual and for H3R screen compounds capable treating pruritus/itch model systems screening their usefulness pruritus.

参考文章(168)
Felix Theeuwes, Pieter Bonsen, Patrick Seck-Lai Wong, Method of delivering drug with aid of effervescent activity generated in environment of use ,(1981)
Reddeppa reddy Dandu, Robert L. Hudkins, Babu G. Sundar, Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands ,(2009)
Jill M Wetter, Huaqing Liu, Lawrence A Black, Thomas C Custer, Kennan C Marsh, Maria G Beconi, Jae Yo Lee, Marlon D Cowart, Octahydro-pyrrolo[3,4-b]pyrrole n-oxides ,(2008)
Timothy W. Lovenberg, Barbara L. Roland, Sandy J. Wilson, Xiaoxia Jiang, Jayashree Pyati, Arne Huvar, Michael R. Jackson, Mark G. Erlander, Cloning and functional expression of the human histamine H3 receptor. Molecular Pharmacology. ,vol. 55, pp. 1101- 1107 ,(1999) , 10.1124/MOL.55.6.1101
Philip Arthur Hipskind, Cynthia Darshini Jesudason, William Joseph Hornback, Don Richard Finley, Terry Patrick Finn, Takako Takakuwa, Histamine h3 receptor agents, preparation and therapeutic uses ,(2005)
Xiaobing San Diego Li, Laura C. San Diego Mcatee, Chandravadan R. San Diego Shah, Ronald L. San Diego Wolin, J. Guy Escondido Breitenbucher, Nicholas I. Poway Carruthers, Phenyl-substituted imidazopyridines ,(2001)
Jr. Constantine D. J. Generales, Apparatus for testing human responses to stimuli ,(1978)
Jason GlaxoSmithKline Witherington, Mark James GlaxoSmithKline Bamford, Sanjeet Singh GlaxoSmithKline Sehmi, David Matthew Glaxosmithkline Wilson, David Kenneth Glaxosmithkline Dean, Benzo d!azepine derivatives for the treatment of neurological disorders ,(2003)
T.-C. He, S. Zhou, L. T. da Costa, J. Yu, K. W. Kinzler, B. Vogelstein, A simplified system for generating recombinant adenoviruses Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 2509- 2514 ,(1999) , 10.1073/PNAS.95.5.2509