Immunohistochemical Analysis of IA-2 Family of Protein Tyrosine Phosphatases in Rat Gastrointestinal Endocrine Cells
作者： Hiroshi Gomi , Chisato Kubota-Murata , Tadashi Yasui , Azuma Tsukise , Seiji Torii
关键词:
摘要: Islet-associated protein-2 (IA-2) and IA-2β (also known as phogrin) are unique neuroendocrine-specific protein tyrosine phosphatases (PTPs). The IA-2 family of PTPs was originally identified from insulinoma cells discovered to be major autoantigens in type 1 diabetes. Despite its expression the neural canonical endocrine tissues, data on gastrointestinal (GECs) limited. Therefore, we immunohistochemically investigated rat tract. In stomach, were expressed GECs that secrete serotonin, somatostatin, cholecystokinin/gastrin-1. addition these hormones, secretin, gastric inhibitory polypeptide glucose-dependent insulinotropic peptide), glucagon-like peptide-1, glucagon, but not ghrelin coexpressed with or duodenal GECs. Pancreatic islet gut hormones PTPs. patterns comparable. These results reveal is a cell type-specific manner extensive pancreo-gastrointestinal enteric plexus suggests their systemic contribution nutritional control through neuroendocrine signaling network.
sagepub.com
sci-hub.se 参考文章(35)
Seiji TORII, Expression and function of IA-2 family proteins, unique neuroendocrine-specific protein-tyrosine phosphatases Endocrine Journal. ,vol. 56, pp. 639- 648 ,(2009) , 10.1507/ENDOCRJ.K09E-157
Atsutaka Kubosaki, Shinichiro Nakamura, Anne Clark, John F. Morris, Abner L. Notkins, Disruption of the Transmembrane Dense Core Vesicle Proteins IA-2 and IA-2β Causes Female Infertility Endocrinology. ,vol. 147, pp. 811- 815 ,(2006) , 10.1210/EN.2005-0638
Naoya Saito, Toshiyuki Takeuchi, Ayumi Kawano, Masahiro Hosaka, Ni Hou, Seiji Torii, Luminal interaction of phogrin with carboxypeptidase E for effective targeting to secretory granules. Traffic. ,vol. 12, pp. 499- 506 ,(2011) , 10.1111/J.1600-0854.2011.01159.X
Tobias R. Zahn, Margaret A. Macmorris, Weijia Dong, Robert Day, John C. Hutton, IDA-1, aCaenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm The Journal of Comparative Neurology. ,vol. 429, pp. 127- 143 ,(2001) , 10.1002/1096-9861(20000101)429:1<127::AID-CNE10>3.0.CO;2-H
Ikuro Takakura, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Suehiro Sakaguchi, Shigeru Katamine, Takahiro Yamaguchi, Hisashi Aso, Kohtaro Miyazawa, Takashi Kanaya, Sachi Tanaka, Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice Histochemistry and Cell Biology. ,vol. 127, pp. 291- 301 ,(2007) , 10.1007/S00418-006-0250-X
M. S. Lan, C. Wasserfall, N. K. Maclaren, A. L. Notkins, IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 6367- 6370 ,(1996) , 10.1073/PNAS.93.13.6367
Sayoko Shimizu, Noriko Saito, Atsutaka Kubosaki, Seo SungWook, Natsumi Takeyama, Takeharu Sakamoto, Yasunobu Matsumoto, Keiichi Saeki, Yoshitsugu Matsumoto, Takashi Onodera, Developmental Expression and Localization of IA-2 mRNA in Mouse Neuroendocrine Tissues Biochemical and Biophysical Research Communications. ,vol. 288, pp. 165- 171 ,(2001) , 10.1006/BBRC.2001.5754
T. Nishimura, A. Kubosaki, Y. Ito, A.L. Notkins, Disturbances in the secretion of neurotransmitters in IA-2/IA-2β null mice: Changes in behavior, learning and lifespan Neuroscience. ,vol. 159, pp. 427- 437 ,(2009) , 10.1016/J.NEUROSCIENCE.2009.01.022
Takuya Nishimura, Shin-ichi Harashima, Hu Yafang, Abner Louis Notkins, IA-2 modulates dopamine secretion in PC12 cells. Molecular and Cellular Endocrinology. ,vol. 315, pp. 81- 86 ,(2010) , 10.1016/J.MCE.2009.09.023
Kenta Nakajima, Guoying Wu, Akikazu Sakudo, Takashi Onodera, Natsumi Takeyama, Distinct subcellular localization of three isoforms of insulinoma-associated protein 2β in neuroendocrine tissues. Life Sciences. ,vol. 88, pp. 798- 802 ,(2011) , 10.1016/J.LFS.2011.02.018