Expression of OP4 (ORL1, NOP1) receptors in vascular endothelium.

摘要: Endothelial cells from rat brain microvessels, human aortic artery and umbilical vein were examined, together with ex vivo capillaries ring sections, for the expression of opioid receptor-like OP-4 mRNA protein. High levels an immunopositive reaction receptor protein detected in endothelial primary established vitro cultures, as well intima rings, where signal was limited to layer. Interaction OP4 its physiological ligand nociceptin caused, cultured cells, activation a mitogen-activated (MAP) kinase cascade. Taken together, these results show that is synthesised functionally expressed presumably starting point some vasoactive mechanism(s).