The molecular events in heavy chain class-switching.

摘要: Heavy chain class-switching is the process by which B lymphoid cells change constant region of immunoglobulin heavy they produce. Class-switching most commonly accomplished recombinationldeletion between switch recombination regions that lie upstream each germline gene. Recent studies support a model to specific directed modulation accessibility these common class-switch system. T cell lymphokines seem be able alter different loci, and thereby direct specificity in cells.