摘要: Abstract Verotoxin-globotriaosyl ceramide (Gb 3 ) binding is the linchpin in disease induced by verotoxin-producing Escherichia coli (VTEC), and defines cell sensitivity, tissue tropism, mode of systemic transport, specific cytotoxic activity internal routeing within sensitive cells. Binding explains epidemiology renal pathology, which may follow VTEC infection. Lipid heterogeneity Gb important binding, define a growth-related signal transduction pathway used verotoxin.
elsevier.com
sci-hub.se 参考文章(66)
S C Li, S K Kundu, R Degasperi, Y T Li, Accumulation of globotriaosylceramide in a case of leiomyosarcoma. Biochemical Journal. ,vol. 240, pp. 925- 927 ,(1986) , 10.1042/BJ2400925
A. D. O’brien, V. L. Tesh, A. Donohue-Rolfe, M. P. Jackson, S. Olsnes, K. Sandvig, A. A. Lindberg, G. T. Keusch, Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis. Current Topics in Microbiology and Immunology. ,vol. 180, pp. 65- 94 ,(1992) , 10.1007/978-3-642-77238-2_4
Richard S. Trompeter, Bernard S. Kaplan, Joel L. Moake, Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura Marcel Dekker, Inc.. ,(1992)
C A Lingwood, H Law, S Richardson, M Petric, J L Brunton, S De Grandis, M Karmali, Glycolipid binding of purified and recombinant Escherichia coli produced verotoxin in vitro. Journal of Biological Chemistry. ,vol. 262, pp. 8834- 8839 ,(1987) , 10.1016/S0021-9258(18)47490-X
S DeGrandis, H Law, J Brunton, C Gyles, C A Lingwood, Globotetraosylceramide Is Recognized by the Pig Edema Disease Toxin Journal of Biological Chemistry. ,vol. 264, pp. 12520- 12525 ,(1989) , 10.1016/S0021-9258(18)63888-8
A. L. Hughes, T. F. Tedder, Liang-Ji Zhou, D. C. Ord, Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain. Journal of Immunology. ,vol. 147, pp. 1424- 1432 ,(1991)
S C Head, M A Karmali, C A Lingwood, Preparation of VT1 and VT2 hybrid toxins from their purified dissociated subunits. Evidence for B subunit modulation of a subunit function. Journal of Biological Chemistry. ,vol. 266, pp. 3617- 3621 ,(1991) , 10.1016/S0021-9258(19)67839-7
H Chart, S M Scotland, B Rowe, Serum antibodies to Escherichia coli serotype O157:H7 in patients with hemolytic uremic syndrome. Journal of Clinical Microbiology. ,vol. 27, pp. 285- 290 ,(1989) , 10.1128/JCM.27.2.285-290.1989
A. Kiarash, B. Boyd, C.A. Lingwood, Glycosphingolipid receptor function is modified by fatty acid content. Verotoxin 1 and verotoxin 2c preferentially recognize different globotriaosyl ceramide fatty acid homologues. Journal of Biological Chemistry. ,vol. 269, pp. 11138- 11146 ,(1994) , 10.1016/S0021-9258(19)78102-2
Yaeta ENDO, Kunio TSURUGI, Takashi YUTSUDO, Yoshifumi TAKEDA, Toshihiro OGASAWARA, Kazuei IGARASHI, Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. FEBS Journal. ,vol. 171, pp. 45- 50 ,(1988) , 10.1111/J.1432-1033.1988.TB13756.X