Mitochondrial Function in Non-ischemic Heart Failure

摘要: Provision for the continuous demand energy from beating heart relies heavily on efficient mitochondrial activity. Non-ischemic cardiomyopathy in which oxygen supply is not limiting results etiologies such as pressure overload. It associated with progressive development of metabolic stress culminating depletion and failure. The mitochondria ventricular walls undergoing non-ischemic are subjected to long periods adaptation support changing milieu, has been described mal-adaptation since it ultimately loss cardiac contractile function. While chronicity exposure stressors, co-morbidities thereby adaptive changes maybe different between ischemic failure, resulting pathology very similar, especially late stage Understanding early-stage failure may guide mitochondrial-targeted therapeutic options prevent progression This chapter reviews findings functional animal models humans most exhibit dysfunction, studies have inconsistent despite confirmed reduction ATP production. also possibility impairment substrate processes upstream discusses potential metabolism-targeted options.