Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis.

摘要: The bioassay-directed isolation of Terminalia chebula fruits afforded four human immunodeficiency virus type 1 (HIV-1) integrase inhibitors, gallic acid ( 1) and three galloyl glucoses 2 - 4). In addition, flavonol glycoside gallates 5 8) from Euphorbia pekinensis containing the moiety also showed inhibitory activity at a level comparable to those 4. By comparison with activities compounds not bearing this moiety, it is proposed that plays major role for inhibition against 3'-processing HIV-1 these compounds.