Interaction of testosterone with inhibin α and βA subunits to regulate prostate gland growth

摘要: Testosterone regulation of prostate gland growth has been shown to involve reciprocal interaction with inhibin and activin. This study was therefore conducted correlate the effect testosterone on proliferation differentiation level expression α βA subunits. Immature dogs were treated for 0, 3, 7, 14 days assessed by morphological immunohistological localization markers. The results showed that treatment resulted in an initial significant increase PCNA index 3 followed a decrease day post-treatment. Interestingly, cell associated structural biochemical changes characteristic glandular stromal gland. These include progressive ductal canalization inter-ductal stroma which apparent from gradual shift vimentin α-actin expression. also had differential β Although constant inhibition subunit mRNA expression, it 7 14. indicated acts first drive undifferentiated prostatic cells then maintain low turnover differentiated cells. Because activin is antagonistic regulator androgens, attenuated stimulatory might be mediated, at least part, interplay between