Small cell carcinoma of the gynecologic tract: A multifaceted spectrum of lesions
作者： Maria Atienza-Amores , Elena Guerini-Rocco , Robert A. Soslow , Kay J. Park , Britta Weigelt
DOI: 10.1016/J.YGYNO.2014.05.017
关键词:
摘要: Abstract Objective Small cell carcinoma (SmCC) of the female genital tract constitutes a diagnostic and clinical challenge given its rarity lack standardized therapeutic approaches. Here we review morphological, molecular features gynecologic SmCCs discuss potential areas for future research. Methods Data this article were identified by searches PubMed, EMBASE Internet using search terms "small carcinoma" or "neuroendocrine "gynecologic", "uterine cervix", "cervix", "uterus", "endometrium", "ovary", "vagina", "fallopian tube" "vulva", research articles published in English between 1972 February 2014 included. Results arising from different organs within share same histopathologic characteristics, which closely resemble those small lung carcinoma. The expression at least one immunohistochemical neuroendocrine marker is common finding. uterine cervix most frequent site SmCC tract. HPV infection seems to play role development cervical but not cancers other sites. FIGO stage an established prognostic factor, particular SCCs cervix. Irrespective site, display aggressive behavior with few reported long-term survivors. management includes surgery, radiotherapy chemotherapy. Conclusions Despite differences etiology risk factors, sites have similar morphologic appearances behavior. Recent genomic analyses revealed driver alterations. We posit that comprehensive characterization may lead identification markers result improvement reproducibility tract, aberrations be exploited therapeutically subgroups disease.
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