Clinical Impact and Reliability of Pleural Fluid Mesothelin in Undiagnosed Pleural Effusions
作者： Helen E. Davies , Ross S. Sadler , Silvia Bielsa , Nicholas A. Maskell , Najib M. Rahman
DOI: 10.1164/RCCM.200811-1729OC
关键词:
摘要: Rationale: Serum mesothelin is a new biomarker for the diagnosis of mesothelioma. Patients with mesothelioma commonly present pleural effusions. To define clinical utility quantification in fluid, we assessed its additional value over fluid cytology and short-term reproducibility reliability after inflammatory processes, including pleurodesis.Objectives: assess diagnostic role effect common factors that may influence measurement accuracy.Methods: Mesothelin was quantified 424 64 serum samples by ELISA. Fluid collected prospectively from 167 patients who presented effusions investigation. Serial were obtained (n = 33) requiring repeated drainage. levels also measured 32) prepleurodesis postpleurodesis.Measurements Main Results: Pleural concentrations significa...
bristol.ac.uk
sci-hub.se 参考文章(41)
R. L. Coffey, Clinical Respiratory Medicine, 2nd ed (Albert RK, Spiro SG, Jett JR) Respiratory Care. pp. 390- ,(2005)
Richard W. Light, Y C Gary Lee, Textbook of Pleural Diseases ,(2008)
Richard K. Albert, Stephen G. Spiro, James R. Jett, Clinical respiratory medicine Mosby Elsevier. ,(2004)
Kathy J. Helzlsouer, Prospective Study of Serum CA-125 Levels as Markers of Ovarian Cancer JAMA: The Journal of the American Medical Association. ,vol. 269, pp. 1123- 1126 ,(1993) , 10.1001/JAMA.1993.03500090059033
J Peto, A Decarli, C La Vecchia, F Levi, E Negri, The European mesothelioma epidemic. British Journal of Cancer. ,vol. 79, pp. 666- 672 ,(1999) , 10.1038/SJ.BJC.6690105
Ian M Thompson, Donna Pauler Ankerst, Chen Chi, M Scott Lucia, Phyllis J Goodman, John J Crowley, Howard L Parnes, Charles A Coltman, Operating Characteristics of Prostate-Specific Antigen in Men With an Initial PSA Level of 3.0 ng/mL or Lower JAMA. ,vol. 294, pp. 66- 70 ,(2005) , 10.1001/JAMA.294.1.66
Hannah Carolan, Alexander Y. Sun, Andrea Bezjak, Qi-Long Yi, David Payne, Gabrielle Kane, John Waldron, Natasha Leighl, Ronald Feld, Ronald Burkes, Shaf Keshavjee, Frances Shepherd, Does the incidence and outcome of brain metastases in locally advanced non-small cell lung cancer justify prophylactic cranial irradiation or early detection? Lung Cancer. ,vol. 49, pp. 109- 115 ,(2005) , 10.1016/J.LUNGCAN.2004.12.004
E. MARSHALL GOLDBERG, LISA M. SIMUNOVIC, SANDRA L. DRAKE, WILLYS F. MUELLER, HARLAND L. VERRILL, Comparison of Serum CA 19–9 and CEA Levels in a Population at High Risk for Colorectal Cancer Hybridoma. ,vol. 8, pp. 569- 575 ,(1989) , 10.1089/HYB.1989.8.569
Armando C. Filie, Christie Copel, Anna Maria Wilder, Andrea Abati, Individual specimen triage of effusion samples: an improvement in the standard of practice, or a waste of resources? Diagnostic Cytopathology. ,vol. 22, pp. 7- 10 ,(2000) , 10.1002/(SICI)1097-0339(200001)22:1<7::AID-DC3>3.0.CO;2-U
Bruce W.S. Robinson, Jenette Creaney, Richard Lake, Anna Nowak, Arthur William Musk, Nicholas de Klerk, Pernilla Winzell, Karl Erik Hellstrom, Ingegerd Hellstrom, Soluble mesothelin-related protein—A blood test for mesothelioma Lung Cancer. ,vol. 49, ,(2005) , 10.1016/J.LUNGCAN.2005.03.020