Glutamate transporter 1-mediated antidepressant-like effect in a rat model of chronic unpredictable stress

摘要: In recent years, more attention has been paid to the role of glutamate transporter 1 (GLT-1, EAAT2) in major depressive disorder (MDD). However, experimental data on brain GLT-1 levels are, some extent, inconsistent human postmortem and animal studies. These discrepancies imply that pathophysiology MDD action antidepressants remain obscure. This work was designed study impact chronic unpredictable stress (CUS) for 2 sessions per day 35 days four weeks fluoxetine (FLX) depressive-like behaviors rats, as well concomitant expression protein hippocampus. Behavioral changes were assessed by sucrose preference open field tests. detected immunohistchemistry Western blot analysis. Our demonstrated animals exposed CUS showed exhibited a significant decrease Chronic FLX treatment reversed behavioral deficits CUS-induced levels. Taken together, our results support reduction studies suggest may be involved antidepressant activity FLX. further notion is an attractive candidate molecule associated with fundamental processes potential, novel pharmacological target MDD.