Synthesis and evaluation of temperature- and glucose-sensitive nanoparticles based on phenylboronic acid and N-vinylcaprolactam for insulin delivery.
作者： Jun-zi Wu , David H. Bremner , He-yu Li , Xiao-zhu Sun , Li-Min Zhu
DOI: 10.1016/J.MSEC.2016.07.078
关键词:
摘要: Poly N-vinylcaprolactam-co-acrylamidophenylboronic acid p(NVCL-co-AAPBA) was prepared from N-vinylcaprolactam (NVCL) and 3-acrylamidophenylboronic (AAPBA), using 2,2-azobisisobutyronitrile (AIBN) as initiator. The synthesis structure of the polymer were examined by Fourier Transform infrared spectroscopy (FT-IR) (1)H-NMR. Dynamic light scattering (DLS), lower critical solution temperature (LCST) transmission electron microscopy (TEM) utilized to characterize nanoparticles, CD used determine if there any changes conformation insulin, cell animal toxicity also investigated. nanoparticles found be monodisperse submicron particles glucose- temperature-sensitive. In addition, have good insulin-loading characteristics, do not affect insulin show low-toxicity cells animals. These may some value for or other hypoglycemic protein delivery.
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sci-hub.se 参考文章(45)
Wei Wang, Maofang He, Chaozhan Wang, Yinmao Wei, Enhanced binding capacity of boronate affinity adsorbent via surface modification of silica by combination of atom transfer radical polymerization and chain-end functionalization for high-efficiency enrichment of cis-diol molecules. Analytica Chimica Acta. ,vol. 886, pp. 66- 74 ,(2015) , 10.1016/J.ACA.2015.06.015
Matthew J Webber, Daniel G Anderson, Robert Langer, Engineering synthetically modified insulin for glucose-responsive diabetes therapy Expert Review of Endocrinology & Metabolism. ,vol. 10, pp. 483- 489 ,(2015) , 10.1586/17446651.2015.1071187
Mamta Joshi, Pratik Choudhary, Multiple Daily Injections OR Insulin Pump Therapy: Choosing the Best Option for Your Patient—An Evidence-based Approach Current Diabetes Reports. ,vol. 15, pp. 81- 81 ,(2015) , 10.1007/S11892-015-0644-Z
Mingming Zhou, Fan Lu, Xiaomei Jiang, Qingshi Wu, Aiping Chang, Weitai Wu, Switchable glucose-responsive volume phase transition behavior of poly(phenylboronic acid) microgels Polymer Chemistry. ,vol. 6, pp. 8306- 8318 ,(2015) , 10.1039/C5PY01441G
Akira Matsumoto, Ryo Yoshida, Kazunori Kataoka, Glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety operating at the physiological pH. Biomacromolecules. ,vol. 5, pp. 1038- 1045 ,(2004) , 10.1021/BM0345413
K. Jeitler, K. Horvath, A. Berghold, T. W. Gratzer, K. Neeser, T. R. Pieber, A. Siebenhofer, Continuous subcutaneous insulin infusion versus multiple daily insulin injections in patients with diabetes mellitus: systematic review and meta-analysis Diabetologia. ,vol. 51, pp. 941- 951 ,(2008) , 10.1007/S00125-008-0974-3
Keisuke Suwa, Munenari Nagasaka, Satoshi Niina, Yuya Egawa, Toshinobu Seki, Jun-ichi Anzai, None, Sugar response of layer-by-layer films composed of poly(vinyl alcohol) and poly(amidoamine) dendrimer bearing 4-carboxyphenylboronic acid Colloid and Polymer Science. ,vol. 293, pp. 1043- 1048 ,(2015) , 10.1007/S00396-014-3490-7
Sibel Emir Diltemiz, Arzu Ersöz, Deniz Hür, Rüstem Keçili, Ridvan Say, 4-Aminophenyl boronic acid modified gold platforms for influenza diagnosis Materials Science and Engineering: C. ,vol. 33, pp. 824- 830 ,(2013) , 10.1016/J.MSEC.2012.11.007
Rujiang Ma, Hao Yang, Zhong Li, Gan Liu, Xiaocheng Sun, Xiaojun Liu, Yingli An, Linqi Shi, Phenylboronic acid-based complex micelles with enhanced glucose-responsiveness at physiological pH by complexation with glycopolymer. Biomacromolecules. ,vol. 13, pp. 3409- 3417 ,(2012) , 10.1021/BM3012715
Ricardo G. Sousa, Alberto Prior-Cabanillas, Isabel Quijada-Garrido, José M. Barrales-Rienda, Dependence of copolymer composition, swelling history, and drug concentration on the loading of diltiazem hydrochloride (DIL.HCl) into poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels and its release behaviour from hydrogel slabs Journal of Controlled Release. ,vol. 102, pp. 595- 606 ,(2005) , 10.1016/J.JCONREL.2004.10.025