Single photon emission and cerebral computerized tomographic scan and transcranial Doppler sonographic findings in eclampsia

摘要: Objective To define more clearly the neuropathophysiology of eclampsia utilising single-photon emission computed tomography (SPECT), cerebral computerised (CT) and transcranial Doppler (TCD) ultrasonography. Design A prospective study. Setting The obstetric unit in King Edward VIII Hospital, a large tertiary referral centre hi Kwa-Zulu Natal, South Africa. Participants Sixty-five women with eclampsia. Interventions Imaging ultrasonographic investigations were performed within 48 hours postpartum. Unenhanced CT scans all SPECT on 63 using Technetium-99m-hexamethylpropyleneamineoxime (99mTc-HMPAO) as tracer regional blood flow. Middle artery flow velocity waveforms measured 2 MHz pulsed ultrasound via transtemporal approach. Main outcome measures Abnormalities scan, scan TCD findings. Results scanning revealed perfusion deficits watershed areas women, 75% whom had concomitant parieto-occipital brain. Hypodensities (cerebral oedema) reported 38 (58.5%), involvement 97.4% cases. Increased measurements middle posterior arteries recorded 36 (85.7%) was performed. Conclusion pathophysiological mechanism eclamptic seizures is primary vasospasm resultant ischaemia oedema involving mainly lobes has been shown to be superior ultrasonography detecting neuropathophysiologic alterations eclampsia. However, each three investigative tools provide its own unique information are necessary research techniques improve our understanding neuropathophysiological seizures.