New indole derivatives as factor Xa inhibitors
作者： Volker Laux , Volkmar Wehner , Marc Nazare , Kurt Ritter
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摘要: The present invention relates to compounds of the formula (I) in which R0 ; R1 R2 R3 R4 R5 R6 R7 Q; V, G and M have meanings indicated claims. I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect suitable, for example, therapy prophylaxis cardiovascular disorders like thromboembolic diseases or restenoses. reversible inhibitors blood clotting enzymes factor Xa (FXa) and/or Vila (FVIIa), can general be applied conditions an undesired activity is cure prevention inhibition intended. furthermore processes preparation I, their use, particular as ingredients pharmaceuticals, pharmaceutical preparations comprising them.
google.com.ar参考文章(99)
Heinz W. Pauls, Michael R. Myers, John Z. Jiang, Wan F. Lau, Alfred P. Spada, Yong Mi Choi-Sledeski, Barbara A. Hanney, Michael R. Becker, Stephen M. Condon, Roderick S. Davis, William R. Ewing, Gregory B. Poli, Wei He, Christopher J. Burns, Aiwen Li, SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS ,(1999)
Volker Laux, Volkmar Wehner, Hans Matter, Marc Nazare, Matthias Urmann, Armin Bauer, Indazole-derivatives as factor Xa inhibitors ,(2004)
Ellen Myra Dobrusin, Dennis Joseph Mcnamara, Richard John Booth, Peter Laurence Toogood, Vara Prasad Venkata Nagendra Josyula, Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors ,(2001)
Nicolas LaChance, Marc Labelle, Claudio Sturino, Dwight MacDonald, PDE IV inhibiting amides, compositions and methods of treatment ,(2001)
Irwin H. Segel, Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems ,(1975)
Jean-Robert Dormoy, Alain Heymes, Synthese industrielle en serie ellipticine. I: Elaboration d'une nouvelle voie d'accès aux 6H-pyrido[4,3:b]carbazoles et analogues: A. Synthèse et étude des précurseurs. Tetrahedron. ,vol. 49, pp. 2885- 2914 ,(1993) , 10.1016/S0040-4020(01)80387-2
Alain Badorc, Danielle Gully, Daniel Frehel, Robert Boigegrain, Pierre Despeyroux, Jean-Pierre Bras, 5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them ,(1994)
Matthias Beller, Thomas H. Riermeier, Palladium‐Catalyzed Amination of Aryl Halides Organic Synthesis Set. pp. 126- 132 ,(2003) , 10.1002/9783527620784.CH22B
Volkmar Wehner, Marc Nazaré, David William Will, Michael Wagner, Hans Matter, Armin Bauer, Herman Schreuder, Imidazole derivatives as factor Xa inhibitors ,(2003)
Michael Leroy Phillips, Edward David Mihelich, Alan M. Warshawsky, INDOLE sPLA2 INHIBITORS ,(1999)