Triggering of Autoimmune Antibody Responses in Syphilis

摘要: Early stimulation of the humoral and cellular immune response is clearly one hallmarks natural experimental syphilis.1 The depth breadth in early stages disease represented by antiphospholipid/anticardiolipin antibodies, antitreponemal antibodies (the majority exhibiting extensive cross-reactions with other pathogenic nonpathogenic treponemes), a vast array autoantibodies to blood cells, serum components, tissue constituents (Table I). Although certain autoimmune diseases may have microbial etiology, syphilis unquestionably an infectious disease. It not, nor does it represent, state. varied antibody responses associated or accompanying infection do, however, appear be triggered as secondary reactions. Were not for fact that Treponema pallidum ubsp. capable inciting immuno pathologic mechanisms, would easy discount presence little more than end result infection-related injury. In fact, destruction alone can favor induction if host proteins are sufficiently altered through enzymatic actions offending organism.