Differential gene expression in the condylar cartilage of growing rabbits with temporomandibular joint anterior disk displacement-A transcriptomic study.

摘要: Internal derangement (ID) in the temporomandibular joint (TMJ) comprises a group of clinical problems with relatively high prevalence. However, temporal changes gene expression condylar cartilage during continuous ID remain unclear. The aim current study is to investigate by microarray analysis, differentially-expressed pattern rabbits from one eight weeks progression. Histological results (hematoxylin and eosin staining) indicated that abnormal collagen fiber arrangements, fragmentation fibrils, inflammatory cell-infiltration were detected four disc specimens, while newly formed vessels, mucoid degeneration, meniscal tears, presence osteoclasts osteoblasts observed at later time points. analysis revealed 6478 genes among all tested transcripts, have greater than two-fold change compared controls. inflammation-associated including ace il1β increased rapidly early stage disease decreased later. In contrast, bone construction-related showed low levels first period also found some such as hla2g, which not been previously reported, be potentially relevant within ID. Our findings provide useful insights into pathological mechanism TMJ.