The association of adiponectin and low-grade inflammation with the course of metabolic syndrome
作者： T.M. Ahonen , J.T. Saltevo , H.J. Kautiainen , E.A. Kumpusalo , M.J. Vanhala
DOI: 10.1016/J.NUMECD.2010.07.001
关键词:
摘要: Abstract Background and aims Metabolic syndrome (MetS) is associated with low-grade inflammation. The connections of adiponectin inflammatory cytokines the course MetS are not well-known. aim this study was to investigate relation inflammation development or resolution MetS. Methods results In town Pieksamaki, Finland, five complete age groups ( n = 1.294) were invited for health check-ups in 1997–1998 first time 2003–2004 second time. final population included 284 men 396 women. defined according National Cholesterol Education Program criteria beginning at end 6-year research period, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra) beta (IL-1β) levels determined from baseline samples. Both male female subjects divided into four diagnosis two check-ups: diagnosed either check-up (No MetS), only (Incident (Resolute both (Persistent MetS). Baseline IL-1Ra IL-1β IL-1β/IL-1Ra -ratio found predict Incident MetS, when adjusted change BMI, age, smoking status physical activity. Our data also suggested that a high level low hs-CRP Conclusion Adiponectin markers can
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