Karyotypic evolution of human meningioma. Progression through malignancy.

摘要: Abstract Cytogenetic analysis of an untreated sarcomatous meningioma from a patient submitted to two surgeries separated by 1 year are reported. The material the first surgery was mostly hypodiploid, with modal chromosome number 42. Alterations 22 were found in 80.6% cells. Four markers involving chromosomes 1, 2, 6, and 22, numerical alterations 8, 9, 10, 13, 14, 15, 18, 19, 20, 21, Y. Although second 45 (17.9% cells), 43.1% its cells hyperdiploid, 73% these being triploid—tetraploid range. Dicentric ring very frequent. still present. There recurrent trisomy 3. To our knowledge, this is cytogenetic description, banding techniques, malignant meningioma.