GABA neurons of the VTA drive conditioned place aversion.
作者： Kelly R. Tan , Cédric Yvon , Marc Turiault , Julie J. Mirzabekov , Jana Doehner
DOI: 10.1016/J.NEURON.2012.02.015
关键词:
摘要: Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABAA receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with …
core.ac.uk
elsevier.com
stanford.edu 
sci-hub.se 参考文章(53)
George Paxinos, Keith B. J. Franklin, The Mouse Brain in Stereotaxic Coordinates ,(2007)
Alice H. Luo, François E. Georges, Gary S. Aston-Jones, Novel neurons in ventral tegmental area fire selectively during the active phase of the diurnal cycle European Journal of Neuroscience. ,vol. 27, pp. 408- 422 ,(2008) , 10.1111/J.1460-9568.2007.05985.X
Tsuyoshi Yamaguchi, Whitney Sheen, Marisela Morales, Glutamatergic neurons are present in the rat ventral tegmental area European Journal of Neuroscience. ,vol. 25, pp. 106- 118 ,(2007) , 10.1111/J.1460-9568.2006.05263.X
O. Valenti, D. J. Lodge, A. A. Grace, Aversive Stimuli Alter Ventral Tegmental Area Dopamine Neuron Activity via a Common Action in the Ventral Hippocampus The Journal of Neuroscience. ,vol. 31, pp. 4280- 4289 ,(2011) , 10.1523/JNEUROSCI.5310-10.2011
J. Amiel Rosenkranz, Deanne M. Buffalari, Anthony A. Grace, Opposing Influence of Basolateral Amygdala and Footshock Stimulation on Neurons of the Central Amygdala Biological Psychiatry. ,vol. 59, pp. 801- 811 ,(2006) , 10.1016/J.BIOPSYCH.2005.09.013
FAY A. GUARRACI, RUSSELL J. FROHARDT, STACEY L. YOUNG, BRUCE S. KAPP, A Functional Role for Dopamine Transmission in the Amygdala during Condtioned Fear Annals of the New York Academy of Sciences. ,vol. 877, pp. 732- 736 ,(1999) , 10.1111/J.1749-6632.1999.TB09312.X
W. Shen, M. Flajolet, P. Greengard, D. J. Surmeier, Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity Science. ,vol. 321, pp. 848- 851 ,(2008) , 10.1126/SCIENCE.1160575
Kelly R. Tan, Matthew Brown, Gwenaël Labouèbe, Cédric Yvon, Cyril Creton, Jean-Marc Fritschy, Uwe Rudolph, Christian Lüscher, Neural bases for addictive properties of benzodiazepines Nature. ,vol. 463, pp. 769- 774 ,(2010) , 10.1038/NATURE08758
Jonathan P. Fadok, Martin Darvas, Tavis M. K. Dickerson, Richard D. Palmiter, Long-Term Memory for Pavlovian Fear Conditioning Requires Dopamine in the Nucleus Accumbens and Basolateral Amygdala PLoS ONE. ,vol. 5, pp. e12751- ,(2010) , 10.1371/JOURNAL.PONE.0012751
Shigeyoshi Fujisawa, György Buzsáki, A 4 Hz Oscillation Adaptively Synchronizes Prefrontal, VTA, and Hippocampal Activities Neuron. ,vol. 72, pp. 153- 165 ,(2011) , 10.1016/J.NEURON.2011.08.018