Inhibitory effect of quercetin on carrageenan-induced inflammation in rats.
作者： Keiko Morikawa , Mitsuko Nonaka , Misa Narahara , Ikuko Torii , Kiichiro Kawaguchi
DOI: 10.1016/J.LFS.2003.06.036
关键词:
摘要: We examined the effect of quercetin on inflammatory response induced by carrageenan in rat. Air pouches were subcutaneously backs rats and injected with carrageenan. The treated either vehicle or at a dose 10 mg/kg one hour before challenge. Fourty-eight after challenge, air removed analyzed. volume, protein amounts cell counts exudation obtained from quercetin-treated animals significantly reduced compared to those vehicle-treated animals. contents PGE(2), TNF-alpha, RANTES, MIP-2 mRNA for cyclooxygenase-2 also suppressed these rats. histological examination displayed suppression pouch tissues As anti-inflammatory flavonols was more less similar level among quercetin-, isoquercitrin- rutin-treated rats, it appeared that sugar parts did not influence effect. Our study indicated modulated response, least part, modulating prostanoid synthesis as well cytokine production.
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