The Basis for Carbapenem Hydrolysis by Class A β-Lactamases: A Combined Investigation using Crystallography and Simulations
作者： Fátima Fonseca , Ewa I. Chudyk , Marc W. van der Kamp , António Correia , Adrian J. Mulholland
DOI: 10.1021/JA304460J
关键词:
摘要: Carbapenems are the most potent β-lactam antibiotics and key drugs for treating infections by Gram-negative bacteria. In such organisms, resistance arises principally from β-lactamase prod...
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