Outcomes in elderly patients with acute coronary syndromes randomized to enoxaparin vs. unfractionated heparin: results from the SYNERGY trial
作者： R. D. Lopes , K. P. Alexander , G. Marcucci , H. D. White , S. Spinler
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摘要: Aims Elderly patients are at high risk from non-ST-segment elevation acute coronary syndromes (NSTE ACS) as well treatment-related complications. Age-associated changes in physiology may alter the and benefit expected therapy. The SYNERGY database was used to study influence of age on treatment outcomes with enoxaparin vs. unfractionated heparin (UFH) high-risk NSTE ACS. Methods results Age analysed a continuous categorical variable ( = 75 years, years) for descriptive purposes. Logistic regression adjust 30-day death, death or myocardial infarction (MI), major bleeding baseline characteristics. Odds ratios compared by within groups. Model interaction terms were test statistically different age. Overall, 9977 randomized had information, whom 25.5% (2540) >= years (>= more cardiovascular factors, prior cardiac disease, higher acuity presentation. After adjustment, advanced (per 10 associated MI [risk odds (ROR): 1.14, P 0.002], (ROR: 1.54, treated enoxaparin, statistical comparisons confirm similar efficacy safety UFH across subgroups demonstrated overall SYNERGY.
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