Modified seb and prophylactics/remedies for immunopathy containing the same
作者： Tomoyuki Koshi , Toshiyuki Edano , Kazuhiko Kimachi , Tsukasa Nishihara , Shigeki Kuwata
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摘要: A novel prophylactic/remedy for immunopathy is provided which not neutralized by a neutralizing antibody to Staphylococcal enterotoxin B (SEB), known as one of superantigens, and may effectively act superantigen. modified SEB having reduced reactivity with (anti-SEB antibody) comprising an active ingredient said SEB. The the present invention be prepared evolutionary molecular engineering technique introducing amino acid substitution in sequence SEB, especially at epitope recognition site anti-SEB
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