Statins and hip fracture risk in men: a population-based case-control study.

摘要: Abstract Purpose To estimate the association between hydroxymethylglutaryl-CoA inhibitor (statin) use and hip fracture. Methods We conducted a population-based case-control study. Cases were 6774 male enrollees in large managed care organization, aged 45 or more years, with an incident fracture from 1997 to 2006. Controls without ( n  = 6774) matched cases on age, race, medical center. Electronic information pharmaceutical was used identify dispensing of statins 1991 forward. Results Overall, 1884 (27.8%) 2150 controls (31.7%) statin before index date (matched odds ratio [mOR] = 0.81, 95% confidence interval [CI] = 0.74–0.87). Adjustment for comorbidity burden strengthened magnitude overall (mOR = 0.68, CI = 0.62–0.74). The adjusted similar across age groups but strongest among men 80 years 0.62, 0.54–0.71) most pronounced African Americans 0.43, 0.28–0.64). Greater duration did not alter ratios. Conclusions These data add growing evidence potential protective effect bone health. However, these results need be replicated prospective study that can account confounding by indication which may explain findings.