The functional interplay between systemic cancer and the hematopoietic stem cell niche.

摘要: Hematopoietic cells are increasingly recognized as playing key roles in tumor growth and metastatic progression. Although many studies have focused on the functional interaction of hematopoietic with cells, few examined regulation hematopoiesis by stem cell (HSC) niche setting cancer. Hematopoiesis occurs primarily bone marrow, processes including expansion, mobilization, differentiation progenitors tightly regulated specialized niche. Loss components or ability to localize relieves HSCs restrictions imposed under normal homeostasis. In this review, we discuss how tumor-derived factors therapeutic interventions disrupt structural regulatory properties niche, resulting invasion malignancies, extramedullary hematopoiesis, myeloid skewing peripheral tissue microenvironments, lymphopenia. The played marrow has implications for therapy-related toxicity successful development immune-based therapies