The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist.

摘要: Methoxyfenozide [N-tert-butyl-N'-(3-methoxy-o-toluoyl)-3,5-xylohydrazide; RH-2485] is the newest diacylhydrazine insecticide to reach marketplace. It binds with very high affinity ecdysone receptor complex (EcR:USP) in lepidopteran insects [Kd = 0.5 nM (Plodia)], where it functions as a potent agonist, or mimic, of insect molting hormone, 20-hydroxyecdysone (20E). exhibits insecticidal efficacy against wide range important caterpillar pests, including many members family Pyralidae, Pieridae, Tortricidae and Noctuidae. most effective when ingested by target caterpillar, but also has some topical ovicidal properties. modestly root systemic, not significantly leaf-systemic. Evidence collected date indicates that methoxyfenozide an excellent margin safety non-target organisms, beneficial insects.