Reactivity increase of dienophiles by change of the ester substituents into the acid chlorides: cycloaddition reaction of the diacid chloride of 3,10-hexacyclo[10.2.1.15,8.02,11.03,10.04,9]hexadeca-6,13-diene-3,10-dicarboxylic acid with quadricyclane
作者： Davor Margetić , Anamarija Briš , Ronald N. Warrener , Douglas N. Butler
DOI: 10.1016/J.TET.2013.06.057
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摘要: Abstract Conversion of the ester substituents on cyclobutene π-bond dimethyl tricyclo[4.2.1.0 2,5 ]nona-3,7-diene-3,4-dicarboxylate to corresponding acid chloride increases cycloaddition reactivity toward quadricyclane so dramatically that reaction temperature can be dropped from 180 °C (preparation title 3,10-diester) room 3,10-diacid chloride). The cycloadduct product, an ring system, is extremely docile and recrystallized unchanged hot methanol.
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