Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance.
作者： Masoud Najafi , Bagher Farhood , Keywan Mortezaee , Ebrahim Kharazinejad , Jamal Majidpoor
DOI: 10.1007/S00432-019-03080-1
关键词:
摘要: Cancer stem cells (CSCs) are highly tumorigenic cell types that reside within specific areas of tumor microenvironment (TME), and endowed with self-renewal resistance properties. Here, we aimed to discuss mechanisms involved in hypoxia-derived CSC targeting for effective cancer therapy. Preferential localization hypoxic niches would help CSCs develop adaptive mechanisms, mediated through the modification responses various stressors and, as a result, show more aggressive behavior. Hypoxia, fact, serves multi-tasking strategy nurture this capacity, complexing targeted therapies.
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