Legionella suppresses the host unfolded protein response via multiple mechanisms.
作者： Sean Treacy-Abarca , Shaeri Mukherjee
DOI: 10.1038/NCOMMS8887
关键词:
摘要: The intracellular pathogen, Legionella pneumophila, secretes ∼300 effector proteins to modulate the host environment. Given intimate interaction between L. pneumophila and endoplasmic reticulum, we investigated role of unfolded protein response (UPR) during infection. Interestingly, show that identifies infection as a form reticulum stress sensor pATF6 is processed generate pATF6(N), transcriptional activator downstream UPR genes. However, able suppress block translation prototypical genes, BiP CHOP. Furthermore, biochemical studies reveal uses two effectors (Lgt1 Lgt2) inhibit splicing XBP1u mRNA spliced XBP1 (XBP1s), an regulator. Thus, demonstrate by multiple mechanisms including blocking causing translational repression. This observation highlights utility powerful tool for studying critical homeostasis
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