The effect of lidocaine on the endothelium damage in rabbit vein grafts.
作者： Yusuf Unal , Oncul Sema , Demirel C Bekir , Yilmazer Demet , Arslan Mustafa
DOI:
关键词:
摘要: OBJECTIVES To investigate the effects of perivascular and intravenous application lidocaine on venous endothelial morphology harvested rabbit vein graft. METHODS This study was conducted in Gazi University Animal Research Laboratory, Ankara, Turkey March 2009. Three ear veins each rabbits (n=6) were used. Control group (Group C, n=6 vessels), segment excised from distal end. Perivascular P, n=6); 2 ml 1% injected area second same ear, excised. Intravascular I, clamped administered intravascular, 5 minutes later, a cm Nitric oxide synthase thiobarbutiric acid reactive substance levels measured, histopathologic examination performed to assess administration. RESULTS Histopathological findings groups P I similar. There lower thiobarbituric substances level (p=0.024) (p=0.041) than control group. activity higher (p=0.026) (p=0.037) when compared C. CONCLUSIONS Our results showed both infiltration intravascular administration could prevent consequences endothelium damage that occurs during harvesting veins.
smj.org.sa参考文章(22)
Erkan Iriz, Omer Kurtipek, Murat Alper, Yusuf Unal, Askin Pekbay, Demet Yilmazer, Mustafa Kavutcu, Effects of lidocaine on membrane stabilization in harvested vein graft storage. Saudi Medical Journal. ,vol. 30, pp. 203- 208 ,(2009)
Hélène Beloeil, Zaid Ababneh, Richard Chung, David Zurakowski, Robert V. Mulkern, Charles B. Berde, Effects of Bupivacaine and Tetrodotoxin on Carrageenan-induced Hind Paw Inflammation in Rats (Part 1)Hyperalgesia, Edema, and Systemic Cytokines Anesthesiology. ,vol. 105, pp. 128- 138 ,(2006) , 10.1097/00000542-200607000-00022
G. Gherardini, U. Samuelson, J. Jernbeck, B. Åberg, N. Sjöstrand, Comparison of vascular effects of ropivacaine and lidocaine on isolated rings of human arteries. Acta Anaesthesiologica Scandinavica. ,vol. 39, pp. 765- 768 ,(1995) , 10.1111/J.1399-6576.1995.TB04167.X
Andrzej Loesch, Michael Dashwood, On the sympathetic innervation of the human greater saphenous vein: relevance to clinical practice. Current Vascular Pharmacology. ,vol. 7, pp. 58- 67 ,(2009) , 10.2174/157016109787354150
Michael R. Dashwood, Kay Savage, Janice C.S. Tsui, Audrey Dooley, Sidney G. Shaw, Maria S. Fernández Alfonso, Lennart Bodin, Domingos S.R. Souza, Retaining perivascular tissue of human saphenous vein grafts protects against surgical and distension-induced damage and preserves endothelial nitric oxide synthase and nitric oxide synthase activity. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 138, pp. 334- 340 ,(2009) , 10.1016/J.JTCVS.2008.11.060
G. Boccara, J. Eliet, Y. Pouzeratte, C. Mann, P. Colson, Pre‐emptive lidocaine inhibits arterial vasoconstriction but not vasopressin release induced by a carbon dioxide pneumoperitoneum in pigs BJA: British Journal of Anaesthesia. ,vol. 90, pp. 343- 348 ,(2003) , 10.1093/BJA/AEG080
Muneera R. Kapadia, Lesley W. Chow, Nick D. Tsihlis, Sadaf S. Ahanchi, Jason W. Eng, Jozef Murar, Janet Martinez, Daniel A. Popowich, Qun Jiang, Joseph A. Hrabie, Joseph E. Saavedra, Larry K. Keefer, James F. Hulvat, Samuel I. Stupp, Melina R. Kibbe, Nitric oxide and nanotechnology: a novel approach to inhibit neointimal hyperplasia. Journal of Vascular Surgery. ,vol. 47, pp. 173- 182 ,(2008) , 10.1016/J.JVS.2007.09.005
Michael Dashwood, Andrzej Loesch, The Saphenous Vein as a Bypass Conduit: The Potential Role of Vascular Nerves in Graft Performance Current Vascular Pharmacology. ,vol. 7, pp. 47- 57 ,(2009) , 10.2174/157016109787354132
Joseph F. Sabik, Bruce W. Lytle, Eugene H. Blackstone, Penny L. Houghtaling, Delos M. Cosgrove, Comparison of Saphenous Vein and Internal Thoracic Artery Graft Patency by Coronary System The Annals of Thoracic Surgery. ,vol. 79, pp. 544- 551 ,(2005) , 10.1016/J.ATHORACSUR.2004.07.047
Michael R. Dashwood, Kay Savage, Audrey Dooley, Xu Shi-Wen, David J. Abraham, Domingos S.R. Souza, Effect of vein graft harvesting on endothelial nitric oxide synthase and nitric oxide production. The Annals of Thoracic Surgery. ,vol. 80, pp. 939- 944 ,(2005) , 10.1016/J.ATHORACSUR.2005.03.042