Neuroendocrine tumors and somatostatin: imaging techniques

摘要: Tumors and metastases bearing the somatostatin receptor subtypes 2 (SSTR2) or SSTR5 can be visualized in vivo after injection of radiolabeled octapeptide analogs like 111In-pentetreotide. The sensitivity 111In-pentetreotide scintigraphy for detection carcinoid tumors is 86-95%. gastrinomas, vasoactive intestinal polypeptide-secreting tumors, glucagonomas as well clinically non-functioning lesions 75-100%. However, insulinoma this 50-60%. generally has a lower rate benign pheochromocytomas than 123I-MIBG scintigraphy, but it have complementary role staging malignant pheochromocytomas. It also used extra-adrenal paragangliomas. Most GH- TSH-secreting pituitary adenomas using negative microprolactinomas ACTH-secreting microadenomas. been successful localization extra-pituitary their metastases, especially occult tumors. A large variety around region express receptors and, therefore, by scintigraphy.