Genetik des Mammacarcinoms

作者: Teresa Wagner , Gudrun Langbauer , Elisabeth Fleischmann , Ernst Kubista

DOI: 10.1007/978-3-7091-6402-0_2

关键词:

摘要: Der Nachweis, das Krebs eine genetisch bedingte Erkrankung ist, gelang erst in diesem Jahrhundert und mus zu den wohl bedeutendsten Entwicklungen der Onkologie gezahlt werden. Epidemiologische, zytogenetische molekulargenetische Untersuchungen stellen die Grundlagen Erforschung genetischer Ursachen dar. Die Krebsentstehung geht von mindestens einer Zelle aus beruht auf Akkumulation mehrerer unabhangiger Mutationen (Bodmer Tomlinson 1996).

参考文章(36)
Peysson R, Ferrari P, Salanon C, Fontana X, Namer M, Bussiere F, C-erb-B2 gene amplification and serum level of c-erb-B2 oncoprotein at primary breast cancer diagnosis. Anticancer Research. ,vol. 14, pp. 2099- 2104 ,(1994)
W. F. Bodmer, Ian Tomlinson, Population genetics of tumours. Ciba Foundation symposium. ,vol. 197, pp. 181- 193 ,(1996) , 10.1002/9780470514887.CH10
W. R. Williams, D. E. Anderson, Genetic epidemiology of breast cancer: further clarification and a response to King and Elston. Genetic Epidemiology. ,vol. 2, pp. 170- 176 ,(1985) , 10.1002/GEPI.1370020208
Esfir Löfman, Alain Puisieux, Nicole Falette, Marie-Pierre Paperin, Isabelle Treilleux, Nigel Tooke, Nadine Peloux, Alain Bremond, Mehmet Ozturk, Anne-Christelle Gratadour, Hervé Mignotte, Mats Inganäs, Prognostic value of P53 gene mutations in a large series of node-negative breast cancer patients. Cancer Research. ,vol. 58, pp. 1451- 1455 ,(1998)
Faina Bogomolniy, Esther Rhei, Patrick I. Borgen, Lan Kang, Mark G. Federici, Jeff Boyd, Mutation Analysis of the Putative Tumor Suppressor Gene PTEN/MMAC1 in Primary Breast Carcinomas Cancer Research. ,vol. 57, pp. 3657- 3659 ,(1997)
C Carlomagno, F Perrone, C Gallo, M De Laurentiis, R Lauria, A Morabito, G Pettinato, L Panico, A D'Antonio, A R Bianco, S De Placido, c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases. Journal of Clinical Oncology. ,vol. 14, pp. 2702- 2708 ,(1996) , 10.1200/JCO.1996.14.10.2702
O T Jóhannsson, J Ranstam, A Borg, H Olsson, Survival of BRCA1 breast and ovarian cancer patients: a population-based study from southern Sweden. Journal of Clinical Oncology. ,vol. 16, pp. 397- 404 ,(1998) , 10.1200/JCO.1998.16.2.397
Kleihues P, Ohgaki H, Estève J, Schäuble B, zur Hausen A, Tumors associated with p53 germline mutations: a synopsis of 91 families. American Journal of Pathology. ,vol. 150, pp. 1- 13 ,(1997)
Oskar Johannsson, Qiu-Xia Zhang, Åke Borg, Håkan Olsson, Karin Haraldsson, Niklas Loman, BRCA2 Germ-Line Mutations Are Frequent in Male Breast Cancer Patients without a Family History of the Disease Cancer Research. ,vol. 58, pp. 1367- 1371 ,(1998)
Michael Kastan, On the TRAIL from p53 to apoptosis Nature Genetics. ,vol. 17, pp. 130- 131 ,(1997) , 10.1038/NG1097-130