Phosphoramide and Oxazaphosphorine Mustards
作者： Joel E. Wright
DOI: 10.1007/978-1-59259-717-8_2
关键词:
摘要: Phosphoramide mustards and their metabolic precursors, the oxazaphosphorine mustards, belong to general class of alkylating agents. Some related compounds, aryl- alkyl-bis(2-chloroethyl)amines, were covered in previous chapter. Two oxazaphosphorines, cyclophosphamide ifosfamide (Fig. 1), are only phosphorylated mustard compounds ordinarily prescribed for cancer treatment today (1). The developmental work that led prominent role medicine outgrowth prospective agents based on structures activities will be presented this
springer.com
sci-hub.st 参考文章(213)
FRANK E. ADAIR, HALSEY J. BAGG, EXPERIMENTAL AND CLINICAL STUDIES ON THE TREATMENT OF CANCER BY DICHLORETHYLSULPHIDE (MUSTARD GAS. Annals of Surgery. ,vol. 93, pp. 190- 199 ,(1931) , 10.1097/00000658-193101000-00026
Julian M. Henwood, Rex N. Brogden, Etoposide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer. Drugs. ,vol. 39, pp. 438- 490 ,(1990) , 10.2165/00003495-199039030-00008
W.P. Brade, K. Herdrich, M. Varini, Ifosfamide-pharmacology, safety and therapeutic potential Cancer Treatment Reviews. ,vol. 12, pp. 1- 47 ,(1985) , 10.1016/0305-7372(85)90011-8
Frederick M. Golomb, Agents used in cancer chemotherapy. American Journal of Surgery. ,vol. 105, pp. 579- 590 ,(1963) , 10.1016/0002-9610(63)90233-2
A. Ghavamzadeh, Treatment of metastatic breast cancer with the combination of ifosfamide, epirubicin and 5-fluorouracil Cancer Chemotherapy and Pharmacology. ,vol. 26, ,(1990) , 10.1007/BF00685424
Allan B. Foster, Michael Jarman, Ryszard W. Kinas, Johannes M. S. Van Maanen, Grahame N. Taylor, John L. Gaston, Ann Parkin, Anthony C. Richardson, 5-Fluoro- and 5-chlorocyclophosphamide: synthesis, metabolism, and antitumor activity of the cis and trans isomers. Journal of Medicinal Chemistry. ,vol. 24, pp. 1399- 1403 ,(1981) , 10.1021/JM00144A006
Peter B. Farmer, Peter J. Cox, Synthesis and antitumor activity of 6-trifluoromethylcyclophosphamide and related compounds. Journal of Medicinal Chemistry. ,vol. 18, pp. 1106- 1110 ,(1975) , 10.1021/JM00245A012
G. Enblad, B. Glimelius, H. Hagberg, C. Lindemalm, Methyl-Gag, Ifosfamide, Methotrexate and Etoposide (Mime) as Salvage Therapy for Hodgkin's Disease and Non-Hodgkin's Lymphoma Acta Oncologica. ,vol. 29, pp. 297- 301 ,(1990) , 10.3109/02841869009090001
Victoria L. Boyd, Joan D. Robbins, William Egan, Susan M. Ludeman, 31P nuclear magnetic resonance spectroscopic observation of the intracellular transformations of oncostatic cyclophosphamide metabolites. Journal of Medicinal Chemistry. ,vol. 29, pp. 1206- 1210 ,(1986) , 10.1021/JM00157A015
Reto Abele, MattiS. Aapro, Jean-Marie Haefliger, Pierre Alberto, Phase I study of cyclohexylamine and lysine salt of mafosfamide. Cancer Chemotherapy and Pharmacology. ,vol. 16, pp. 182- 183 ,(1986) , 10.1007/BF00256173