Progenitor cell-derived extracellular vesicles: an emerging diagnostic and therapeutic tool for renal disease

A. Ranghino, V. Cantaluppi, C. Grange, L. Vitillo, F. Fop, L. Biancone, M.C. Deregibus, C. Tetta, G.P. Segoloni, G. Camussi, Endothelial progenitor cell-derived microvesicles improve neovascularization in a murine model of hindlimb ischemia. International Journal of Immunopathology and Pharmacology. ,vol. 25, pp. 75- 85 ,(2012) , 10.1177/039463201202500110

Bärbel Brunswig-Spickenheier, Janna Boche, Christof Westenfelder, Frauke Peimann, Achim D. Gruber, Kai Jaquet, Korff Krause, Jozef Zustin, Axel R. Zander, Claudia Lange, Limited immune-modulating activity of porcine mesenchymal stromal cells abolishes their protective efficacy in acute kidney injury. Stem Cells and Development. ,vol. 19, pp. 719- 729 ,(2010) , 10.1089/SCD.2009.0494

Stefania Bruno, Cristina Grange, Federica Collino, Maria Chiara Deregibus, Vincenzo Cantaluppi, Luigi Biancone, Ciro Tetta, Giovanni Camussi, Microvesicles Derived from Mesenchymal Stem Cells Enhance Survival in a Lethal Model of Acute Kidney Injury PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0033115

Luciana A Reis, Fernanda T Borges, Manuel J Simoes, Andrea A Borges, Rita Sinigaglia-Coimbra, Nestor Schor, None, Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0044092

Ying Zhou, Huitao Xu, Wenrong Xu, Bingying Wang, Huiyi Wu, Yang Tao, Bin Zhang, Mei Wang, Fei Mao, Yongmin Yan, Shuo Gao, Hongbing Gu, Wei Zhu, Hui Qian, None, Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro Stem Cell Research & Therapy. ,vol. 4, pp. 34- 34 ,(2013) , 10.1186/SCRT194

Giovanni Camussi, Maria Chiara Deregibus, Vincenzo Cantaluppi, Role of stem-cell-derived microvesicles in the paracrine action of stem cells. Biochemical Society Transactions. ,vol. 41, pp. 283- 287 ,(2013) , 10.1042/BST20120192

Markus Bitzer, Iddo Z. Ben-Dov, Thomas Thum, Microparticles and microRNAs of endothelial progenitor cells ameliorate acute kidney injury Kidney International. ,vol. 82, pp. 375- 377 ,(2012) , 10.1038/KI.2012.152

Maria Chiara Deregibus, Vincenzo Cantaluppi, Raffaele Calogero, Marco Lo Iacono, Ciro Tetta, Luigi Biancone, Stefania Bruno, Benedetta Bussolati, Giovanni Camussi, Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood. ,vol. 110, pp. 2440- 2448 ,(2007) , 10.1182/BLOOD-2007-03-078709

Florian Tögel, Zhuma Hu, Kathleen Weiss, Jorge Isaac, Claudia Lange, Christof Westenfelder, Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. American Journal of Physiology-renal Physiology. ,vol. 289, pp. 31- 42 ,(2005) , 10.1152/AJPRENAL.00007.2005

Vincenzo Cantaluppi, Stefano Gatti, Davide Medica, Federico Figliolini, Stefania Bruno, Maria C. Deregibus, Andrea Sordi, Luigi Biancone, Ciro Tetta, Giovanni Camussi, Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cells Kidney International. ,vol. 82, pp. 412- 427 ,(2012) , 10.1038/KI.2012.105