Structures and Functions of Viral 5' Non-Coding Genomic RNA Domain-I in Group-B Enterovirus Infections.
作者： Marie Glenet , Laetitia Heng , Domitille Callon , Anne-Laure Lebreil , Paul-Antoine Gretteau
DOI: 10.3390/V12090919
关键词:
摘要: Group-B enteroviruses (EV-B) are ubiquitous naked single-stranded positive RNA viral pathogens that responsible for common acute or persistent human infections. Their genome is composed in the 5' end by a non-coding region, which crucial initiation of replication and translation processes. domain-I secondary structures can interact with cellular proteins to form ribonucleoprotein (RNP) complexes regulating genomic replication, whereas domains-II -VII (internal ribosome entry site, IRES) known ribosomal subunits initiate process. Natural terminally deleted forms lacking some have been described EV-B induced murine Recent vitro studies evidenced loss RNP modulate infectivity levels Moreover, disruption could impair sensing RIG-I (Retinoic acid inducible gene I) MDA5 (melanoma differentiation-associated protein 5) receptors, way overcome antiviral innate immune response. Overall, natural genomes resulting various be major key players host-cell interactions driving development
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