Improved sensitivity of nanowire Bio-FETs operated at high-frequency: A simulation study

摘要: Silicon Nanowire (SiNW) Bio-FETs emerged as promising candidates for DNA and proteins detection, but static screening severely limits the response to analytes located beyond approximately one Debye length from surface. In this paper we investigate first time potential advantages of small signal SiNW in wet environment up frequency above electrolyte's dielectric relaxation cut-off by means three-dimensional simulations calibrated on experiments. We find that limit is overcome at high frequency, where change capacitance due analyte binding weakly sensitive distance electrode, salt concentration hardly controllable surface charges.