Extrapolation of acenocoumarol pharmacogenetic algorithms.

摘要: Abstract Introduction Acenocoumarol (ACN) has a narrow therapeutic range that is especially difficult to control at the start of its administration. Various dosing pharmacogenetic-guided algorithms have been developed, but further work on their external validation required. The aim this study was evaluate extrapolation pharmacogenetic for ACN as an alternative development specific algorithm given population. Material and methods predictive performance, deviation, accuracy, clinical significance five (EU-PACT, Borobia, Rathore, Markatos, Krishna Kumar) were compared in 189 stable patients representing all indications anticoagulant treatment. Results correlation between dose predictions models ranged from 7.7 70.6% percentage with correct prediction (deviation ≤ 20% actual dose) 5.9 40.7%. EU-PACT Borobia most accurate our setting evidenced best performance. Conclusions Among studied, demonstrated potential extrapolation.