Hemodynamic effects on hepatic blood flow of a selective β2-adrenoceptor agonist, clenbuterol, in rat

摘要: Acute clenbuterol administration (50 μg/kg, i.v.) to anesthetized normotensive rats, produce a marked reduction in the mean blood pressure, (MBP), about 58 mm Hg. Indocyanine Green clearance analysis (control, 1.83±0.15: clenbuterol, 1.10±0.20 ml/min/100 g,P<0.05) showed that action hepatic vascular bed is opposite its systemic vasodilator effects. The flow (HBF) appears significantly reduced 8.24±0.35: 3.83±0.71 whereas uptake and excretion proceedings were apparently not affected (control extraction coefficient, 0.225±0.024: 0.300±0.04, NS).These findings show HBF follows effects produced by clenbuterol.