Preoperative Chemotherapy: Updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27
作者： Priya Rastogi , Stewart J Anderson , Harry D Bear , Charles E Geyer , Morton S Kahlenberg
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摘要: Purpose National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol B-18 was designed to determine whether four cycles of doxorubicin cyclophosphamide (AC) administered preoperatively improved breast cancer disease-free survival (DFS) overall (OS) compared with AC postoperatively. B-27 the effect adding docetaxel (T) preoperative on tumor response rates, DFS, OS. Patients Methods Analyses were limited eligible patients. In B-18, 751 patients assigned receive AC, 742 postoperative AC. B-27, 784 followed by surgery, 783 T 777 surgery then T. Results from show no statistically significant differences in DFS OS between two groups. However, there trends favor che...
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