Retention of plasmid DNA in mammalian cells is enhanced by binding of the Epstein-Barr virus replication protein EBNA1.

摘要: The capacity to bind the Epstein-Barr viral protein EBNA1 increases retention of plasmid in dividing cells. This requires binding multiple molecules for function, although significant activity is seen with fewer sites than are required activate replication or transcription. regions that increased overlap those activation transcription and replication. similarities traits support DNA indicate both may be mediated by interactions an overlapping set cellular proteins.