Association of IL-6, IL-10, and TNF-α Gene Polymorphism with Malnutrition Inflammation Syndrome and Survival Among End Stage Renal Disease Patients
作者： Richa Sharma , Suraksha Agrawal , Anita Saxena , R.K. Sharma
关键词:
摘要: During end stage renal disease (ESRD) inflammatory pathways are activated which may lead to malnutrition inflammation syndrome (MIS). In the present study, 257 ESRD patients and 200 controls were included. Cytokine levels genotyping was done by polymerase chain reaction–restriction fragment length polymorphism enzyme-linked immunosorbent assay (ELISA). Risk estimated through binary logistic regression. Cox proportional hazards regression Kaplan–Meier used for survival analysis. Tumor necrosis factor TNF-α-308 AA conferred 3.6-fold higher susceptibility (P=0.001) TNF-α (P=0.05). TNF-α-238 associated with 3.3-fold (P=0.002). IL-6-174 CC genotype 3-fold risk along IL-6 (P=0.001). IL-10-1082 GG exhibited 2.2-fold (P=0.013). IL-10-592 AA/-819 TT genotypes high C reactive protein (P=0.02) low IL-10 (P=0.03) levels. TNF-α-...
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