Bone marrow transplant indications for childhood leukemias: achieving a consensus. The EBMT Pediatric Diseases Working Party

摘要: During the "2nd International Course on Bone Marrow Transplantation in Children" a multiple choice questionnaire bone marrow transplant indications for children with acute leukemias was distributed aim of achieving consensus. The answers obtained from twenty representatives fourteen European countries during meeting were analyzed and assigned to one following groups: I. definitive indication: when more than 75% participants favour; II. acceptable 50% 74% III. requires further investigation: 25% 49% IV. no less 24% favour. In lymphoblastic leukemia circumstances considered indication allogeneic (BMT) matched sibling donor (MSD): infancy, "high risk" (HR) patients 1st complete remission (CR1); CR2 after an early relapse (defined as occurring up six months stopping therapy). Patients experiencing meningeal late later therapy) indication. Further investigation required order better define role BMT isolated testicular relapse. If MSD is not available, HR CR1 patients, relapse, definite unrelated (MUD). This latter group haploidentical if MUD available. autologous (ABMT) extramedullary all whom lacked MSD's. myeloblastic (AML), MSD. ABMT cases lacking AML BMT.