Simulating Biochemical Systems

作者: David J. Barnes , Dominique Chu

DOI: 10.1007/978-1-4471-6762-4_7

关键词:

摘要: This chapter introduces the reader to principles underlying Gillespie’s widely-used stochastic simulation algorithm (SSA), for exact modeling of chemical reactions involving relatively small numbers molecules. We also look at Gibson and Bruck’s improvements SSA, in order support larger reactions, as well more recent variation by Slepoy, Thompson Plimpton. All these techniques are illustrated with Java implementations a discussion their complexity. introduce Dizzy SGNSim toolkits, which implement some approaches, along tau-leap approximation reaction delays.

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